Polycystic ovary syndrome benefits from vitamin D supplementation

Researchers looked at randomized, placebo-controlled trials that compared the effect of vitamin D supplementation with placebo or metformin in polycystic ovary syndrome (PCOS) patients. Nine studies were included, involving 502 women presenting with PCOS. Vitamin D supplementation had significant effect on the improvement of follicular development with a higher number of dominant follicles. Differences in regular menstrual cycles were also observed when metformin plus vitamin D was compared with metformin alone.