New research shows that taking 300 IU vitamin D per kilogram daily for 4 months significantly improves autism symptoms in children 3-10 years old. A total of 109 children with autism with normal vitamin D levels were randomly assigned to receive vitamin D3 or placebo for 4 months. At the end of the treatment period, Childhood Autism Rating Scale (CARS) scores significantly improved for children in the vitamin D group, with average scores decreasing by about 6.5 points in those receiving vitamin D. The CARS scores evaluated many factors, including emotional response, relating to people, body use, listening response, visual response, imitation, adaptation to change, and general autistic impression.
In a study of 1790 Japanese adults, higher circulating vitamin D levels were associated with a decreased likelihood of having metabolic syndrome. Compared with those with vitamin D levels lower than 20 ng/mL, the risk of metabolic syndrome was reduced by 21% with levels of 20 – 29 ng/mL, and by 48% with levels above 30 ng/mL.
Researchers looked at randomized, placebo-controlled trials that compared the effect of vitamin D supplementation with placebo or metformin in polycystic ovary syndrome (PCOS) patients. Nine studies were included, involving 502 women presenting with PCOS. Vitamin D supplementation had significant effect on the improvement of follicular development with a higher number of dominant follicles. Differences in regular menstrual cycles were also observed when metformin plus vitamin D was compared with metformin alone.
In a recent meta-analysis, the lower the blood vitamin D levels were, the higher the risk of total cardiovascular disease (CVD) events and CVD mortality.
Patients with inflammatory back pain, axial spondyloarthritis are more likely to have severe vitamin D deficiency compared to the general population. Vitamin D deficiency was associated with higher disease activity and severity.
There is often an increased calcium demand during pregnancy and lactation resulting in temporary bone loss. In a study of 56 adolescent mothers, supplementation with calcium and vitamin D during pregnancy reduced postpartum bone loss. The study also found that genetics plays a role in the effectiveness of supplementation.